The Health Risks of Being Left-Handed

One reason that not more is known about lefties is that many studies of how the brain works prohibit left-handers from participating because their brain wiring is known to be different, says Robin Nusslock, a psychology professor at Northwestern University in Evanston, Ill., who uses neuroimaging to study mood disorders.

A potential pathway between prenatal stress and brain wiring could be cortisol, the body’s main stress hormone, which can interfere with brain development, says Carsten Obel, a professor at the public-health department at Aarhus University in Denmark who has conducted research on the prenatal environment and risk of disease. Cortisol is able to pass over the placenta barrier to influence the baby.

Several studies show that stressful life events, such as the death of a loved one or job loss, during pregnancy increase the risk of having non-right-handed children. In one study of 834 Danish mothers and their 3-year-old children, Dr. Obel and his colleagues found that mothers who reported multiple stressful events during their third trimester of pregnancy and experienced distress were more than three times as likely to have a mixed-handed child, 17% compared with 5%, according to the 2003 paper published in Developmental Medicine & Child Neurology.

Another large study followed 1,700 Swedish mothers and children until the kids were 5 years old. It found that mothers with depressive symptoms or who underwent stressful life events while pregnant were more likely to have left- or mixed-handed children. The work was published by Dr. Rodriguez and her colleagues in 2008 in the Journal of Child Psychology and Psychiatry.

Experts suggest that left- and mixed-handedness could be used as a risk factor for possible psychiatric or developmental conditions, along with behavioral difficulties, such as having a hard time in school. The presence of such risk factors could prompt early evaluation for those conditions, they say.

—Christina Tsuei contributed to this article.

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